As they protested against proposals for Ultra Low Emissions Zones (Ulez) development, hundreds of demonstrators descended on London Bridge.
Sadiq Khan, the Labour mayor, wants to include all of outside London in the ultra-low emission zone for the city.
A High Court judge ruled last month that five councils with a Conservative majority might contest the scheme.
If the Ulez expansion is approved, drivers in outer London would start paying a daily cost of £12.50 on August 29 if their cars do not satisfy the required emissions criteria.
In an effort to stop plans to extend the Ulez reach over the entirety of London, hundreds voiced their opinions as they stopped traffic moving across the city center bridge.
Twelve-year veteran scout leader John Hemming-Clark estimated that it will now cost him £25 to drive a group of kids camping on the weekends.
The 63-year-old told the PA news agency: “I’m a scout leader and I have a 10-year-old car, it’s going to cost me £25 every week to take the children to camps.
“Why I think it’s so unjust is because Sadiq Khan’s manifesto had no mention of this, there’s real hardships in the likes of Bromley and people need their cars to see relatives or go to the hospital.
“Central London is one thing but Khan introducing Ulez to outer London unopposed is another. At the moment, we have local protests but if this does go ahead and people realise this does affect the wider population, God knows what will happen.”
The crowd of demonstrators was screaming “get Khan out” as they marched back and forth over the bridge while sounding bells and whistles.
Speaking after the release of his new book, Breathe: Tackling The Climate Emergency, on Friday, Mr Khan said: “My mum’s got asthma, she’s 82 (and lives nearby), I’ve got two children, 23 and 21, but I’ve also got nephews and nieces, neighbours and friends.
“Members of my family could get dementia, heart disease or cancer directly attributable to the poor-quality air. So, of course, there’s a self interest in relation to the impact on me, my family and friends.”
Protesters disputed Mr. Khan’s claim that Ulez was implemented to improve the quality of the air.
Jane Green said: “We want to stop the poorest of people from having an additional cost to their livelihoods.
“Those who have the older cars are the ones who can’t afford the charge or to buy a new car.
“If you look at the air quality website regularly, you’d see it’s a lie, the air of London is not toxic at all.
“Just look, it’s not toxic.”
Drivers would have to pay each mile of their journey across the capital, according to Trevor Adams, who told PA that it was one step closer to pay per mile.
He said: “If you look at the readings, the worst areas are in the London Underground, not on the streets.
“This is the first thing I’ve ever felt strong enough to come out on the streets for.”
Theresa Villiers, a former Cabinet minister, urged lawmakers to support her law reform at the beginning of the month so that ministers may participate in decisions affecting air quality and transportation.
“In my 18 years as an MP… almost nothing has provoked such strong opposition as the Mayor of London’s plan to expand the ultra low emission zone,” Ms. Villiers, who represents Chipping Barnet in outside London, said in a statement to the Commons.
“It comes up on almost every doorstep and at almost every meeting. People stop me in the street to tell me how strongly they feel about this, and over 50,000 have signed the Conservative petition.
“That is why I am bringing forward this Bill to give the Government power to overrule Mayor Khan and stop Ulez expansion.”